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In a presentation entitled “ADAPTIR™ Platform, a Novel Platform for Development of Immuno-Oncology Therapeutics,” Dr. Blankenship presented new in vivo, in vitro, pharmacokinetic (PK) and stability data highlighting the advantages of using the ADAPTIR platform to develop novel immuno-oncology therapeutics.
“The field of bispecific therapeutics is a rapidly emerging area in biotechnology and parallels the development of monoclonal antibodies many decades ago, but with greater therapeutic promise," said Dr.
As pioneers in this field, Aptevo has developed the ADAPTIR platform to engage the immune system in a targeted, controlled fashion. Data presented at the conference showed that ADAPTIR molecules offer key advantages over other bispecific formats, derived in part from the flexible and modular nature of the ADAPTIR structure. Potent biological activity can be achieved, while retaining standard manufacturing characteristics. ADAPTIR bispecific molecules utilize a homodimeric format that avoids the potential manufacturing issues associated with heterodimeric bispecific formats. In addition, ADAPTIR bispecific molecules have demonstrated antibody-like serum half-life in rodents (up to 12 days in mice), in the data presented at PEPTALK.”
Data were also presented showing that ADAPTIR molecules have unique properties for redirecting T-cell cytotoxicity (RTCC) compared to other bispecific platforms, including a favorable cytokine release profile. Preclinical studies presented by Dr. Blankenship at PEPTALK and recently published in the
Two ADAPTIR molecules are currently undergoing clinical trials, with several more bispecific immunotherapies in preclinical development. The advantages of the ADAPTIR platform provides an opportunity for diverse therapeutic applications in the future.
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Aptevo Therapeutics Stacey JurchisonSenior Director, Investor Relations and Corporate Communications 206-859-6628 JurchisonS@apvo.com