Aptevo Therapeutics Begins Phase 1 Clinical Trial of APVO210 a Novel Bispecific Antibody for the Treatment of Autoimmune and Inflammatory Diseases
Unique Mechanism of Action Suppresses Inflammation and Immune Activation Without Promoting Pro-Inflammatory Lymphocyte Stimulation
Preliminary Phase 1 Data Read-outs Anticipated Q3 and Q4 2019
There is a growing body of data to support APVO210 as a novel, first-in-class targeted cytokine immunotherapy. Preclinical data published in the journal Frontiers in Immunology highlighted the activity of APVO210 as a potent and selective agent to generate a population of regulatory T cells that may play a key role in the suppression of inflammatory processes associated with pathogenic autoimmune and inflammatory conditions, such as psoriasis, inflammatory bowel disease, rheumatoid arthritis, graft-versus-host disease, and lupus, as well as other diseases where there is antigen-driven activation of T lymphocyte-mediated disease.
“Although a number of IL-10 therapeutics have been developed and tested in the clinic by other companies, the results of these studies have been disappointing, potentially due to the undesired pro-inflammatory effects of IL-10,” said
“We achieve this by using our ADAPTIR bispecific antibody scaffold to deliver a modified form of IL-10 to antigen presenting cells by targeting CD86 without stimulating IL-10 responses on resting and activated lymphocytes,” continued Dr. Gross. “As a result, APVO210 has the potential to harness the desired anti-inflammatory effects of IL-10 without promoting concomitant undesired pro-inflammatory responses. We are very excited to begin our clinical development program for APVO210 to determine if the preclinical properties observed to date can be replicated in a clinical setting.”
About the APVO210 Phase 1 Clinical Trial
The Phase 1 clinical trial, which is being conducted in
The study will be conducted in 2 stages; the first stage will assess single ascending doses (SAD) of APVO210, followed by an evaluation of multiple ascending doses (MAD) of APVO210 administered by intravenous (IV) infusion either weekly or biweekly over 4 weeks. The study is expected to enroll a maximum of 64 subjects in the initial SAD dose cohort and up to 40 subjects in the MAD dose cohort.
Following a determination of a recommended clinical dose, Aptevo anticipates conducting an expansion phase of the clinical trial, which will enroll up to 40 patients with psoriasis or ulcerative colitis. In this segment of the trial, the recommended clinical dose will be given for 12 weeks by IV infusion with the objective of gathering longer-term safety data for APVO210 and preliminary data on the clinical activity of APVO210 in this patient population.
Aptevo anticipates reporting data from the initial SAD dose cohort in the third quarter of 2019 and reporting preliminary Phase 1 safety data in the fourth quarter of 2019.
“We expect enrollment to proceed relatively quickly since APVO210 will be initially evaluated in healthy volunteers to assess safety,” commented Dr.
Cytokines such as IL-10 function by promoting or suppressing a variety of cellular functions, including inflammatory responses. Unregulated inflammation is believed to be responsible for a variety of chronic and acute inflammatory and autoimmune disorders. The cytokine IL-10 is known to play a key role in suppressing inflammation, but is known to exert stimulatory effects on lymphocytes, promoting B-cell proliferation, immunoglobulin production and cytotoxic T-cell function, thus potentially reducing its overall therapeutic utility for immunosuppression.
Conversely, APVO210 is designed to deliver a modified form of IL-10 to suppress inflammation and immune activation without lymphocyte stimulation. Importantly, APVO210 also retains the ability to mediate the differentiation of tolerogenic dendritic cells and antigen specific T regulatory cells (Tr1)
APVO210 is believed to improve the anti-inflammatory properties of IL-10 in two ways. First by specifically targeting cells expressing CD86, such as monocytes, macrophages, and dendritic cells, while eliminating the undesired stimulation of lymphocytes including resting and activated T and B lymphocytes expressing the IL-10 receptor. Aptevo believes that the absence of lymphocyte stimulation associated with APVO210 may reduce the toxicities previously observed in clinical studies testing repeat administration of IL-10 in humans. If confirmed, this could potentially allow for improved dosing and enhanced efficacy. Additionally, pre-clinical studies of APVO210 show that it has a longer half-life in non-human primates (approximately 40 hours) compared to IL-10, which is approximately 4 hours. An increased half-life should support an opportunity for improved dosing regimens.
About Autoimmune Diseases
More than 80 different types of autoimmune diseases have been identified. Some, such as Type 1 diabetes, multiple sclerosis and rheumatoid arthritis are well known. Others, however, are rare and difficult to diagnose. Collectively, autoimmune diseases are among the most prevalent diseases worldwide, and in
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Source: Aptevo Therapeutics Inc.